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KMID : 1101420170490040390
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Korean Journal of Clinical Laboratory Science
2017 Volume.49 No. 4 p.390 ~ p.394
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Survey of Unexpected Antibodies Identified at a General Hospital in Jeju
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Chong Moo-Sang
Lee Kyu-Taeg
Cho Young-Kuk
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Abstract
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Unexpected antibody screening and identification tests are highly important in the prevention of hemolytic transfusion reactions. Therefore, it is highly recommended to perform unexpected antibody screening test in all transfusion candidates. Here, the frequency and distribution of unexpected antibodies identified in Jeju for the past 3 years were evaluated. Between Jan 2014 and Dec 2016, unexpected antibody screening test was performed for 10,360 sera of transfusion candidates in Jeju general hospital using a column agglutination method with the Ortho BioVue system (Ortho-clinical Diagnostics, Raritan, NJ, USA). Eighty-seven (0.84%) of 10,360 cases that underwent unexpected antibiotics screening showed positive results. Among them, unexpected antibodies were identified in 41 cases (0.40%). Unidentified antibodies were detected in 8 cases (19.51%) and autoantibodies were detected in 3 cases (7.32%). The anti-E antibody included in warm antibodies were detected most frequently in 8 cases (19.51%); 6 cases (14.63%) of anti-E + anti-c antibody and 3 cases (7.32%) of anti-Lea+anti-Leb. Anti-Lea and anti-Leb antibodies were detected in 2 cases (4.88%), respectively. The anti-D, anti-Dia, anti-Fyb, anti-Jka, anti-Jkb, anti-M and anti-P1 were detected in 1 case (2.44%). Complex antibodies were detected in 1 case (2.44%) in anti-C+anti-D and anti-E+anti-c+anti-Jkb, respectively. In this study, we analyzed the frequency and distribution of unexpected antibodies in one general hospital for the past 3 years. However, there has been a general increase in multicultural families and foreign workers in Jeju, and it would be a meaningful study to compare the frequency and distribution of unexpected antibodies.
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KEYWORD
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Antibody screening test, Antibody identification test, Unexpected antibody
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